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Tuesday, 09 October 2018 19:42

Bumps and Blemishes: Causes and Care of Sebaceous Hyperplasia

Written by Alexandra J. Zani

There are numerous skin anomalies that are observed with clients throughout the course of a professional’s practice. Identifying them, their underlying causes and possible remedies requires an understanding of the science of the skin, organs, and their disorders and diseases. Moreover, knowledge of performing a thorough assessment and possible reasons for the occurrence of various nodules, depressions, lesions, and pilosebaceous (hair follicle) abnormalities requires further study.
Sebaceous hyperplasia are small, yellowish growths that develop on the skin, normally on the face. It is one of many clinical forms of hyperplasia.1

 

EXPLORING HYPERPLASIA

 

First, it is important to understand hyperplasia, generally. The term hyperplasia (Greek, “hyper” meaning “over” and “plasis” meaning “formation”) is defined as the enlargement of an organ or tissue caused by an increase in the reproduction rate of cells. It is also referred to as hypergenesis, an increase in the amount of organic tissue resulting from cell proliferation. Hyperplasia occurs after a response to a stimulus whereby there is an increase in the number of normal cells due to increased demand.2 Hyperplasia may be physiological or pathological.

 

Physiological

 

Physiological hyperplasia is the normal response to a specific subject to regulatory control mechanisms such as hormones. Cells remain the same size, but increase in number. An example of stimuli would be a hormonal increase or growth factor, such as the female breast during puberty or in pregnancy for the proliferation of milk-secreting glandular cells in the breast. Hyperplasia occurs in the endometrium during the proliferation phase of a menstrual cycle. Another example is the proliferation of the basal layer in the epidermis to counteract skin loss or chronic inflammatory response, or to compensate damage or disease in other parts of the body.3

 

Pathological

 

Pathological hyperplasia occurs if there is an excess of hormone or growth factor stimuli during the presence of disease. such as in the prostate gland during aging. Hyperplasia in the endometrium is a result of a hormone producing an ovarian tumor. Hyperplasia of the breast manifests as hyperplastic lesions in the breast that may lead to a more abnormal pattern of growth, increasing cancer risk. Hyperplasia in adrenal glands manifests as pituitary tumors. Hyperplasia in parenchymal organs in acromegaly is abnormal growth of hands, feet, and face caused by overproduction of growth hormone by the pituitary gland.

 

DYSPLASIA – DYSFUNCTIONAL CELL GROWTH

 

Abnormal stimuli can lead to dysplasia involving the dysfunctional cell growth during morphological changes. There are four ways cells can become dysplastic: with hypertrophy, cells can grow large in size; hyperplasia can stem from an increase in cell number; in atrophy, cells can decrease or shrink in number; and with metaplasia, cells can change type.4

 

These changes occur due to some of the normal stimuli to cells and can be non-carcinogenic, such as chronic irritation from smoke. In dysplasia, the cells can look abnormal under a microscope, however may not be cancerous. Hyperplasia and dysplasia may or may not become cancer.1

 

The stimuli could also be carcinogenic, which may cause genetic damage to the cells. Dysplasia is often part of the pre-malignant process. As an example, stratified squamous cells are bound to the basement membrane. With an abnormal stimulus, such as a genetic abnormality, cells lose general regulation of growth, proliferation, and ability to differentiate. They begin with a low-grade dysplasia and are not too different from the original cells. Without removal of the stimulus, however, the dysplasia gets worse, moving from medium to high grade dysplasia. The cells become very different from their original state and neoplastic cells may develop where an abnormal growth of tissue forms called a tumor. High-grade dysplasia can become cancerous.

 

SEBACEOUS HYPERPLASIA

 

Sebaceous hyperplasia is a benign and non-contagious condition that occurs when sebaceous glands become enlarged with trapped sebum. It may be more common during middle-age and among the elderly. Individuals who have had more sun exposure are more likely to get it. There may also be a genetic component to this condition. Sebaceous hyperplasia is more prevalent in immunosuppressed patients and those on immunosuppressant medication, such as cyclosporine.5

 

Lesions can be single or multiple – as well as slightly yellowish and soft – with small papules on the face around the cheeks, nose, and forehead. They can also appear as a basal cell, thus may require medical diagnosis to verify. Closer examination shows sebaceous hyperplasia as being depressed or pitted at the center of the lesion. They are sometimes confused with comedonal acne. Moreover, they can become irritated if attempts are made to extract them.

 

THE HAIR FOLLICLE

 

The pilo-sebaceous unit (hair follicle) contains sebaceous glands that excrete sebum through a duct system into the follicle. Sebum travels up the hair shaft onto the surface of the skin where it becomes part of the mix of microflora of the acid mantle. Cells that form the sebaceous gland are called sebocytes and begin their life cycle in the highly mitotic basal cell layer. During the maturation and differentiation of sebocytes they increase amounts of lipid that migrate toward the central excretory duct. At this point, they release their lipid contents into the follicle.6 

 

Sebaceous glands are very androgen sensitive. Their activity and size may vary dependent upon age and circulating hormone levels.7 Sebaceous and sweat glands account for most of the androgen metabolism in the skin.

 

Sebocytes contain androgen-metabolizing enzymes – 5-alpha-reductase type 1, 3 beta-hydroxysteroid dehydrogenase, and 17-beta hydroxysteroid dehydrogenase type II. The enzymes metabolize weaker circulating androgens into the more potent androgens that bind to receptors within the sebocytes, causing an increase in the size and metabolic rate of the sebaceous gland. The activity of 5-alpha-reductase is higher in the scalp and facial skin. Testosterone and dihydrotestosterone stimulate more sebaceous activity.

 

Androgens stimulate the sebaceous glands, especially during puberty. During the aging process, androgen hormones decrease.8 The sebaceous gland activity decreases, as well as the natural cell turnover. There may be a backup of sebocytes within the gland resulting in enlargement of the gland.

 

TREATMENT AND CARE

 

It is very difficult to eradicate sebaceous hyperplasia completely, since it is a systemic condition. Topical retinoids and azelaic acid have been employed to assist in preventing the sebaceous hyperplasia from forming, since they assist in the skin’s natural desquamation rate. Medical intervention using laser or excision may make some improvement. However, there is risk of scarring or skin discoloration. It is more about keeping these conditions under control through maintaining optimum health in the skin.

 

A more pro-active approach for improving the appearance of the skin begins with understanding the biological changes and alterations that occur during the aging process, especially post-menopause. There is a mitigation of cell signaling and metabolic rate. It is imperative to maintain a healthy lifestyle through good nutrition; consuming anti-inflammatory foods, antioxidants, and essential fatty acids; adequate intake of water; and rest. Reduce stress levels through massage therapy, walking, and mindful practices, such as yoga and meditation. Perform treatments that support the health of the skin, maintaining the integrity of the barrier function. Avoid the use of aggressive treatments that compromise or wound the skin. It is more important to be mindful of supporting the underlying structures of the skin in the dermis and epidermis through treatment that encourages the skin’s natural repair mechanisms. The use of enzymes, nourishing serums, and rejuvenating treatments utilizing microcurrent or LED have proven effects for rebuilding collagen and reducing inflammation with marked improvement of the appearance of the skin.

 

Home care should be biomimetic to the skin utilizing vitamin A, C, and E, as well as peptides, phytoextracts, and natural lipids. Ceramides, fatty acids, and shea butter (contains phosphatidylcholine) are examples of ingredients that support the health of the skin.

 

References
1 National Cancer Institute Dictionary of Cancer Terms, s.v. “Hyperplasia,”
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/hyperplasia.
2 5MinuteSchool. “Hyerplasia - Physiological vs Pathological | Explained in 2 Minutes!”.
YouTube video, 2:09. Posted [Oct. 2016]. https://www.youtube.com/watch?v=-jzJqpf1xnE.
3 Wikipedia, s.v. “Hyperplasia,” last modified May 8, 2018,
https://en.wikipedia.org/wiki/Hyperplasia.
4 Learn Oncology. “Dysplasia: The Progression of Cancer”. YouTube video, 4:19. Posted [July
2015]. https://www.youtube.com/watch?v=Gh_1PfLKqg4.
5 Oakley, Amanda, Vanessa Ngan, and Clare Morrison. “Sebaceous hyperplasia.”  DermNet NZ.
https://www.dermnetnz.org/topics/sebaceous-hyperplasia.
6 Robles, David T. “Sebaceous Hyperplasia.” Medscape.
https://emedicine.medscape.com/article/1059368overview#a5.   
7 Ibid
8 Palmer, Angela. “Sebaceous Hyperplasia Causes, Symptoms, and Treatments.” Verywell
Health. https://www.verywellhealth.com/sebaceous-hyperplasia-causes-symptoms-and-
treatments-4144250.

 

ZaniAlexandra J. Zani is an international educator, researcher, and author with a background in cell biology and medicine. Her passion for education resulted in receiving numerous advanced certifications, both in the United States and abroad. Zani earned an instructor license for aesthetics/cosmetology, is NCEA certified, certified in Oncology Esthetics®, and the Pastiche Method® of Skin Analysis. She is a member of the International Association for Applied Corneotherapy (IAC). Zani presents education for advanced aesthetic technology, including microcurrents, LED, and non-ablative laser. She is a specialist in the anti-aging sciences, including the effects of nutrition, lifestyle, and the mind/body connection.

Sunday, 01 July 2018 20:55

Redness

Written by Erin Madigan-Fleck, N.M.D., C.D.T., L.E., co-owner of Intellective Aesthetic Advanced Esthetic Training and owner of Naturophoria

redness2Cherry angioma: common skin growth that can develop anywhere on the body for individuals 30 years and older. It may be caused by genetics, chemical exposure, excess estrogen, a vitamin C deficiency, or fatty liver tendencies.

 

 

 

Petechiae: occurs generally as a result of pinpoint bleeding beneath the skin. Causes include: trauma, sunburn, bacterial infections, excoriation, scurvy, injury, medications, and various autoimmune diseases.

 

 

 

 

redness3Malar rash: the hallmark, butterfly-shaped rash that accompanies acute, cutaneous lupus, and is very sensitive to light.

 

 

 

 

 

redness4

Spider angioma: a telangiectasis located slightly below the surface of the skin with a fixed central spot and trailing extensions radiating outwards, resembling the likeness of a spider’s web. It is present in 10 to 15 percent of healthy adults and children.

 

 

 

 

 

redness5Senile purpura: reddish-purple macule caused by bruising, medications, and sunlight. The surrounding skin is thin and has fragile blood vessels and reduced collagen.

As time rolls on, many minor skin abnormalities appear, affecting aging clients’ psyche. Treatment for any anomalism is highly sought-after, as current society values radiant, youthful, and healthy-looking skin.There has been a dramatic increase in photo-aging, skin disorders, and cancers due to the declining ozonosphere. The destructive penetration of ultraviolet rays wreaks havoc on the skin. One of the least understood abnormalities is sebaceous hyperplasia or sebaceous gland hyperplasia.

Historically, psoriasis was not always understood or treated effectively. Although treatments and attitudes towards the disease have evolved, those living with the disease still endure much difficulty. Today, understanding the history, clinical types, contributing factors, and available treatments of psoriasis can help professionals provide relief to clients who may be suffering from it.

Tuesday, 30 January 2018 10:33

Educating Clients on Folliculitis

Written by

Folliculitis is a form of skin irritation characterized by tender red spots on the skin that originate from the hair follicle. It results when bacteria enter the hair follicle and becomes infected, creating a red spot or pustule on the skin. Folliculitis can occur on any area of the body, but it is most common on the more sensitive areas, such as the chest, back, and bikini area. Although folliculitis is not completely avoidable, there are important tips to consider to help reduce the chances of it occurring.

Tuesday, 24 January 2017 06:30

Drugs and Their Effects on the Skin

Written by

A study published by the Journal of the American Medical Association concluded that the prevalence of prescription drug use in America among people 20 years of age and older had risen to 59 percent in 2012 from 51 percent just 12 years earlier. During the same period, the percentage of people taking five or more prescription drugs nearly doubled from eight to 15 percent.1 Another study cites the United States as consuming 75 percent of the world's prescription drugs.2

Monday, 25 April 2016 14:28

Taking a Closer Look at the Aesthetic Concerns of the Periorbital Region

Written by Ahmed Abdullah, M.D., F.A.C.S., F.I.C.S.

It is said that the eyes provide a window to the soul, but for those who suffer from aesthetic conditions in this area, the view their eyes offer may be a bit misleading. Clients often complain that puffy lower eyelids, dark undereye circles, and excessive creasing in the eye area give the impression that they are tired or stressed out when, in reality, these problems usually have little to do with such factors.

Tuesday, 22 March 2016 15:37

The Truth About Hormones

Written by

Hormones, which are produced by the endocrine system, regulate a person’s immunity, reproduction, mood, metabolism, growth and overall physical development. There are three types of hormones (estrogen, androgen, and the thyroid hormone) that each have their own responsibilities and obligations. It is well known that some of the most common skin conditions (including acne, dry skin, and hyperpigmentation) can be the result of hormones being out of equilibrium.

There is a great correlation between the morphology of a skin condition and what is chosen for correction in both treatments and the cosmetic chemistry found in product lines. At times, there may be a great deal of emphasis placed on a brand or isolated ingredients without realizing that a manifested skin condition requires research and contemplation going beyond what is visually apparent. Products are directly formulated to impact the skin. A key factor is to realize that the skin care professional should perform a thorough skin analysis, following an intelligent pathway that leads to discovering the underlying cause of a skin condition. This information becomes a mainstay as we continue to build the ideal skin correction program for clients.

Wednesday, 30 July 2014 10:21

The Emotional Aspect of Treating Skin Conditions

Written by Michelle D’Allaird, L.E.

As aestheticians, we must understand that we do not treat skin conditions. Skin conditions are treated by those with an M.D. after their name. As skin care professionals, it is our job to enhance the health of the skin with our products and services. In order to do this, what we do in the treatment room is all about the customer and their emotions. We are taught in aesthetics school that our emotions are to be checked at the door.

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