Layering serums is trending across many social media platforms, often ignoring what is specific about a particular serum’s formula. Most influencers are familiar with serums that have only one or two actives at most and conclude that layering many serums is the best method to improve skin and correct several skin conditions. In short, they assume a serum cannot contain numerous actives and cannot correct several skin problems at the same time. There are alternatives.

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Actives are chosen for the benefits they deliver to skin; multiple benefits are desired by virtually everyone. Nevertheless, it is not necessary to use more than one or two serums.A well formulated serum can hold numerous actives in high percentages several peptides, biosaccharide gum-1, resveratrol, stem cells, numerous botanicals, algae, vitamins, minerals, and more. It is the art and science of formulating high-end products versus formulating simple formulas. There are exceptions, such as vitamin C, that should not be added to such a formula, justifying the use of a separate serum. A vitamin C serum can be layered (waiting a few minutes between the two serums) or rotated in the morning and night.

Some ingredients that could be deemed incompatible in the same serum can be used in the same routine. For example, a serum made with stable vitamin C, aloe, and hyaluronic acid can be followed by a glycolic acid-based moisturizer a few minutes later.Another example is to try utilizing a toner made with a natural, plant-based retinol followed by a serum with a technically contraindicated ingredient.

Selling numerous serums may be a chosen sales strategy by some vendors and influencers, but using fewer serums made with numerous active ingredients may be a more attractive option, delivering skin results in less time and more economically.

Éminence Organic Skin Care

Citrus & Kale Potent C+E Serum

Fast-absorbing, advanced serum for all skin types. This potent dose of non-irritating Vitamin C is stabilized by botanically-derived ferulic acid to deliver optimal antioxidant benefits and improve the appearance of skin.


Guardian Calming Complex

Restore skin’s natural barrier function with Guardian Calming Complex. It soothes sensitized skin and reduces the appearance of redness, irritation, and acne-related inflammation.

Outcrease Retinol Trifecta Serum by Dermelect Cosmeceuticals

Raya Cosmetics

24K Gold Serum

This age-defying, silky treatment combines pure 24 karat gold with the power of antioxidants, botanical extracts, and essential oils.

DermaConcepts/ Environ Skin Care

Youth EssentiA Vita-Peptide C- Quence Serum 4

Vita-Peptide C-Quence Serum 4 contains an optimum concentration of vitamin A and C that helps combat the visible signs of aging – creating the appearance of even, smoother, and healthier–looking skin.



AnteAGE Microneedling Solution

Growth factors, cytokines, and hyaluronic acid combine to achieve anti-inflammatory and rejuvenating results with minimal discomfort and downtime. 

Eve Taylor North America

Revitalising Aromatic Serum No. 5

A replenishing, aromatic serum to boost elasticity and suppleness, while improving the signs of aging.  Rosewood and sweet orange help to increase cell turnover and encourage a radiant complexion.

GLOWBIOTICS Probiotic Skincare

GLOWBIOTICS Probiotic HydraGlow Cream Oil

This unique, light-reflecting, cream oil, includes probiotics, powerful antioxidants, and minerals to help prevent signs of aging and improve skin tone, revealing a healthy glow. 

Viktoria De’Ann Peptide Cosmeceuticals


PEPTI-a.c.n.e uses a blend of amino acid complexes to create and maintain a healthier skin barrier, allowing the skin’s natural defense mechanisms to combat blemish-prone conditions related to bacteria quorum signaling.

C Eye Serum Advance+ by iS Clinical


Emepelle Serum

Addresses the root cause of accelerated aging from estrogen deficient skin non-hormonally with exclusive MEP technology, antioxidants, peptides, and niacinamide.